Neural Tube Defects and Vitamin Prophylaxis
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چکیده
In the early 1980s, two studies (1,2) suggested that a reduction in the prevalence at birth of neural tube defects could be achieved in mothers given periconceptional multivitamin and/or folic acid supplementation. This claim led to considerable interest in Ireland, where there is a high prevalence of neural tube defects. It was considered that the case for supplementation had not been made conclusively in these original studies and that further trials were necessary. A study group was set up in Ireland to coordinate work on this problem. In the Dublin Maternity Hospitals a retrospective study was carried out between 1970 and 1975 to determine the risk of recurrence of neural tube defects. The recurrence rate for the mothers, based on follow-up to the end of 1981, was 5.5% (3). A randomized double-blind trial was initiated in 1982 to determine whether periconceptional supplementation with either folic acid alone or a multivitamin preparation alone can reduce the recurrence risk of neural tube defects in mothers with previously affected offspring from 5% to 1% or less. The patients entered in the trial are randomly allocated to one of three treatment groups: (a) folic acid only; (b) multivitamin only; and (c) folic acid and multivitamin. Supplementation is for a minimum of 3 months before conception and for the first 3 months postconception. Compliance is also being monitored.
منابع مشابه
HYPERVITAMINOSIS A-INDUCED CENTRAL NERVOUS SYSTEM DEFECTS
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متن کامل
Effect of arsenic on neural tube in mouse embryo and relation to reduced folate carrier (RFC-1)
Arsenic is an important environmental toxicant which is usually found in drinking water in inorganic form. The hypothesis tested in this investigation is; arsenic exposure causes neural tube defects (NTDs) andthese defects of the central nervous system are more likely related to folate deficiency during fetal life. In this study, sodium arsenate was administered via intraperitoneal route at a r...
متن کاملMaternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification.
OBJECTIVE Folic acid fortification has reduced neural tube defect prevalence by 50% to 70%. It is unlikely that fortification levels will be increased to reduce neural tube defect prevalence further. Therefore, it is important to identify other modifiable risk factors. Vitamin B(12) is metabolically related to folate; moreover, previous studies have found low B(12) status in mothers of children...
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تاریخ انتشار 2006